article In the past few years, researchers at the University of Illinois, Urbana-Champaign, have discovered that nightshades are able to reduce inflammation, reduce the signs of heart disease and prevent premature death from type 2 diabetes.
Now, new research by the team of researchers at Northwestern University shows nightshaded vegetables can also lower cholesterol levels in mice, which may lead to prevention of coronary artery disease in people.
The research is published online in the journal Cell Metabolism.
In this study, the researchers fed mice high doses of vitamin C and vitamin E for two weeks.
The mice had lower levels of LDL, a type of bad cholesterol.
The researchers also found that the mice who received the vitamin C diet had lower cholesterol and lower blood pressure, and lower levels than those who received a placebo.
The findings are similar to results from previous studies, which have shown that night shaded vegetables, as well as the high levels of antioxidants, can lower LDL and reduce the risk of cardiovascular disease in humans.
The study was a preliminary study, so the researchers can’t say if nightshading vegetables will prove effective in treating people with cardiovascular disease, but they do hope it could help people living with diabetes.
“It’s important to understand that we have this complex, heterogeneous array of nutrients and dietary approaches, and the results of this work are really interesting,” said lead author David C. Whelan, PhD, professor of nutrition at the UIC College of Pharmacy and an associate director of the UIRS program in the College of Veterinary Medicine.
The scientists were able to isolate the vitamin E in the nightshADE vegetables.
This antioxidant is an ingredient found in green vegetables and can reduce LDL levels.
“The green vegetables are one of the most important sources of vitamin E because it is a food source, it’s a source of vitamin K and it is an important nutrient for our body,” Whelas said.
“And we know that vitamin E is able to lower the levels of cholesterol in the blood.”
The vitamin E has been shown to reduce the levels and reduce LDL in some animal studies.
In humans, vitamin E deficiency, which is a condition that occurs when vitamin E levels are too low, can increase the risk for type 2 diabetics.
“When vitamin E goes up, LDL goes down.
The vitamin E increases the levels,” Whatan said.
Vitamin E deficiency is common in people with heart disease.
“And if you have vitamin E deficiencies, it can lead to heart disease,” Wharan said, noting that vitamin supplements are available that can help people avoid deficiencies.
The UIC researchers used mice to test the effects of vitamin A and C. The researchers then used a genetic tool called ELISA, which uses a specific gene to identify the genetic material of an organism, to find out which plants are producing the vitamin A. They were able at the end of the study to identify nightshaves.
The scientists used a combination of ELISA and other genetic tests to identify which nightshaved plants were the source of the vitamin, and found nightshakes were the ones that produced vitamin A, as opposed to the green nightshaders.
The next step was to determine how the vitamin-C, vitamin-E, and antioxidants affected LDL.
The team found that vitamin C did not affect LDL levels, but it did lower the concentrations of the LDL cholesterol marker, a marker for heart disease risk.
“There’s some evidence that vitamin A reduces LDL cholesterol and also reduces the inflammatory response to LDL,” Whaman said in a press release.
“But the data is not very strong, so we are continuing to look at it in more detail.
We do know that antioxidant vitamins increase LDL cholesterol, but we don’t know whether they have an effect on inflammatory response, which might be the important factor in the prevention of heart attacks and strokes,” Wshan said adding that the research is ongoing.”
We are continuing our work to determine the best way to utilize vitamin A in our diet to reduce cholesterol,” Whellan said with hopes that the findings will help people with type 2 heart disease avoid heart attacks, strokes and other conditions.